AiCubator Residents
Universitätsklinikum Hamburg-Eppendorf
There is currently no specific antiviral therapy against BKPyV, which causes severe disease in immunosuppressed patients. The project builds on a well-established workflow from phenotypic screening to mode of action (MoA) and will focus on key experiments to understand cytotoxicity and selectivity in infected primary cells and complex tissues to evaluate the inhibitor for further development.
Universitätsklinikum Erlangen
Researchers from the Institute for Clinical and Molecular Virology at the Universitätsklinikum Erlangen guided by Prof. Dr. Manfred Marschall in cooperation with academic partners at the Friedrich-Alexander University of Erlangen-Nürnberg, discovered unique structural and functional properties of the globular domain of the cytomegalovirus-specific nuclear egress complex (NEC), thereby nominating generally the herpesviral NECs as novel potential targets for therapy strategies against herpesvirus infections.